I am a right-handed shooter. This layout works great for me. The slide release, thumb safety, and magazine release are all perfectly positioned for the right-hander of average to large hand size. The slide locks back on an empty magazine -- thumb up the safety, punch the mag release, insert in a loaded magazine, pull back on the slide a little, release, thumb down the safety, and you are ready to shoot some more.
I need more magazines. This will be a problem with this firearm for a while since it is a new introduction and doesn't have the aftermarket accessories that are available for the Browning Buckmark and Ruger Mark I,II,III pistols. The same is true of holsters. I'm getting by with a holster for a 5" to 6" barrel length at the moment.
The pistol also comes with a trigger lock, an accessory rail to replace the rear sight rail, and an Allen wrench for take-down.
Advantage? I can't imagine a .22 auto being any easier and less stressful to break down for cleaning.
Another advantage is that removing and replacing barrels is going to be a snap. I suspect S&W designed this with an eye toward extensive customization in the future.
I am happy with mine the way it is. I am scrounging .22LR every chance I get because I have such a blast shooting the Victory. I would guess I have run in the neighborhood of 400 rounds through it with absolutely no problems. I've used Remington subsonics, Federal auto target rounds, Aquila Interceptors, CCI Stingers and Velocitors, and CCI subsonics with no hiccups or failures to fire.
Other than making me smile, I'm not sure what good it is, but I guess that's good enough. It would be a fun, challenging squirrel gun. It will handle small varmints and pests, if necessary. A few rounds into the bloody triangle would ruin a home invader's day. I don't really expect to use it for much except target-shooting, though.
This is not for certain, but it would be interesting to test the Victory against, say, a Ruger 10/22 in penetration tests with the same ammo. I might get around to that at some point. Who knows? I might even make a video.